EGFR exon 20 insertions are rare somatic alterations in non-small cell lung cancer (NSCLC). They occur with a frequency of 4 % to 12 % of all EGFR alterations and show a large heterogeneity of inserted or duplicated amino acids. EGFR exon 20 insertions lead to therapy failure to first-, second- and third-generation tyrosine kinase inhibitors (TKI), but recently new therapy approaches such as with…
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